TargetMol

ML399

Product Code:
 
TAR-T24484
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24484-5mg5mg£850.00
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TAR-T24484-50mg50mg£1,661.00
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Quantity:
TAR-T24484-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
ML399 is the menin-- MLL interaction inhibitor that acts by demonstrating strong and selective effects in MLL leukemia cells and validating specific mechanism of action.
CAS:
1560968-49-1
Formula:
C27H28FN3O2
Molecular Weight:
445.538
Purity:
0.98
SMILES:
O[C@](C1CCN(CCCOc2ccc(cc2)C#N)CC1)(c1cccc(F)c1)c1ccccn1

References

1. Senter T, Gogliotti RD, Han C, Locuson CW, Morrison R, Daniels JS, Cierpicki T, Grembecka J, Lindsley CW, Stauffer SR. Progress towards small molecule menin-mixed lineage leukemia (MLL) interaction inhibitors with in vivo utility. Bioorg Med Chem Lett. 2015 Jul 1;25(13):2720-5. doi: 10.1016/j.bmcl.2015.04.026. Epub 2015 Apr 25. PubMed PMID: 25987377. 2. Senter T, Gogliotti R, Han C, Locuson CW II, Morrison R, Daniels JS, Cierpicki T, Grembecka J, Lindsley CW, Stauffer SR. Progress towards small molecule inhibitors of the Menin-Mixed Lineage Leukemia (MLL) interaction with in vivo utility. 2013 Apr 15 [updated 2015 Feb 11]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK280055/ PubMed PMID: 25834909.