TargetMol

Neladenoson dalanate HCl

Product Code:
 
TAR-T24526
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T24526-5mg5mg£850.00
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TAR-T24526-50mg50mg£1,661.00
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TAR-T24526-100mg100mg£2,079.00
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Further Information

Bioactivity:
Neladenoson dalanate HCl is a potent, selective, orally active partial agonist of adenosine A1 receptor (EC50: 0.1 nM).
CAS:
1239235-25-6
Formula:
C35H35Cl2N7O4S2
Molecular Weight:
752.73
Purity:
0.98
SMILES:
Cl.C[C@H](N)C(=O)N[C@@H](C)C(=O)OCCOc1ccc(cc1)-c1c(C#N)c(SCc2csc(n2)-c2ccc(Cl)cc2)nc(N2CCCC2)c1C#N

References

1. Meibom D, Albrecht-K?pper B, Diedrichs N, H?bsch W, Kast R, Kr?mer T, Krenz U, Lerchen HG, Mittendorf J, Nell PG, S?ssmeier F, Vakalopoulos A, Zimmermann K. Neladenoson Bialanate Hydrochloride: A Prodrug of a Partial Adenosine A(1) Receptor Agonist for the Chronic Treatment of Heart Diseases. ChemMedChem. 2017 May 22;12(10):728-737. doi: 10.1002/cmdc.201700151. Epub 2017 May 10. PubMed PMID: 28488817. 2. Baltos JA, Vecchio EA, Harris MA, Qin CX, Ritchie RH, Christopoulos A, White PJ, May LT. Capadenoson, a clinically trialed partial adenosine A(1) receptor agonist, can stimulate adenosine A(2B) receptor biased agonism. Biochem Pharmacol. 2017 Jul 1;135:79-89. doi: 10.1016/j.bcp.2017.03.014. Epub 2017 Mar 23. PubMed PMID: 28344125. 3. Dinh W, Albrecht-K?pper B, Gheorghiade M, Voors AA, van der Laan M, Sabbah HN. Partial Adenosine A1 Agonist in Heart Failure. Handb Exp Pharmacol. 2017;243:177-203. doi: 10.1007/164_2016_83. Review. PubMed PMID: 27770217. 4. Voors AA, D?ngen HD, Senni M, Nodari S, Agostoni P, Ponikowski P, Bax JJ, Butler J, Kim RJ, Dorhout B, Dinh W, Gheorghiade M. Safety and Tolerability of Neladenoson Bialanate, a Novel Oral Partial Adenosine A1 Receptor Agonist, in Patients With Chronic Heart Failure. J Clin Pharmacol. 2017 Apr;57(4):440-451. doi: 10.1002/jcph.828. Epub 2016 Nov 9. PubMed PMID: 27624622.