TargetMol

NHI-2

Product Code:
 
TAR-T24530
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

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CodeSizePrice
TAR-T24530-5mg5mg£270.00
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TAR-T24530-50mg50mg£833.00
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Quantity:
TAR-T24530-100mg100mg£1,219.00
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This product comes from: United States.
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Further Information

Bioactivity:
NHI-2 is an inhibitor of LDHA that acts by reducing lactate production in HeLa cells.
CAS:
1269802-97-2
Formula:
C17H12F3NO3
Molecular Weight:
335.282
Purity:
0.98
SMILES:
COC(=O)c1cc2c(cc(cc2n1O)-c1ccccc1)C(F)(F)F

References

1. Czy? DM, Willett JW, Crosson S. Brucella abortus Induces a Warburg Shift in Host Metabolism That Is Linked to Enhanced Intracellular Survival of the Pathogen. J Bacteriol. 2017 Jul 11;199(15). pii: e00227-17. doi: 10.1128/JB.00227-17. Print 2017 Aug 1. PubMed PMID: 28559292; PubMed Central PMCID: PMC5512224. 2. Fava A, Colica C, Plastino M, Messina D, Cristiano D, Opipari C, Vaccaro A, Gorgone G, Bosco F, Fratto A, De Bartolo M, Bosco D. Cognitive impairment is correlated with insulin resistance degree: the "PA-NICO-study". Metab Brain Dis. 2017 Jun;32(3):799-810. doi: 10.1007/s11011-017-9977-4. Epub 2017 Feb 23. PubMed PMID: 28229380. 3. Lea MA, Guzman Y, Desbordes C. Inhibition of Growth by Combined Treatment with Inhibitors of Lactate Dehydrogenase and either Phenformin or Inhibitors of 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase 3. Anticancer Res. 2016 Apr;36(4):1479-88. PubMed PMID: 27069123. 4. Daniele S, Giacomelli C, Zappelli E, Granchi C, Trincavelli ML, Minutolo F, Martini C. Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and death. Sci Rep. 2015 Oct 23;5:15556. doi: 10.1038/srep15556. PubMed PMID: 26494310; PubMed Central PMCID: PMC4616042.