TargetMol

NS4591

Product Code:
 
TAR-T24547
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24547-5mg5mg£850.00
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TAR-T24547-50mg50mg£1,661.00
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Quantity:
TAR-T24547-100mg100mg£2,079.00
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Further Information

Bioactivity:
NS4591 is a modulator of SK-IK channels.
CAS:
273930-52-2
Formula:
C11H12Cl2N2O
Molecular Weight:
259.13
Purity:
0.98
SMILES:
CCn1c2ccc(Cl)c(Cl)c2n(CC)c1=O

References

1. Comerma-Steffensen SG, Carvacho I, Hedegaard ER, Simonsen U. Small and Intermediate Calcium-Activated Potassium Channel Openers Improve Rat Endothelial and Erectile Function. Front Pharmacol. 2017 Sep 20;8:660. doi: 10.3389/fphar.2017.00660. eCollection 2017. PubMed PMID: 28993731; PubMed Central PMCID: PMC5619997. 2. Kroigaard C, Kudryavtseva O, Dalsgaard T, Wandall-Frostholm C, Olesen SP, Simonsen U. K(Ca)3.1 channel downregulation and impaired endothelium-derived hyperpolarization-type relaxation in pulmonary arteries from chronically hypoxic rats. Exp Physiol. 2013 Apr;98(4):957-69. doi: 10.1113/expphysiol.2012.066340. Epub 2012 Dec 13. PubMed PMID: 23243147. 3. Rosenbaum ST, Larsen T, Joergensen JC, Bouchelouche PN. Relaxant effect of a novel calcium-activated potassium channel modulator on human myometrial spontaneous contractility in vitro. Acta Physiol (Oxf). 2012 Jun;205(2):247-54. doi: 10.1111/j.1748-1716.2011.02384.x. Epub 2011 Dec 22. PubMed PMID: 22099068. 4. Nielsen JS, Rode F, Rahbek M, Andersson KE, R?nn LC, Bouchelouche K, Nordling J, Bouchelouche P. Effect of the SK/IK channel modulator 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591) on contractile force in rat, pig and human detrusor smooth muscle. BJU Int. 2011 Sep;108(5):771-7. doi: 10.1111/j.1464-410X.2010.10019.x. Epub 2011 Jan 11. PubMed PMID: 21223472.