TargetMol

PAO-PDT

Product Code:
 
TAR-T24593
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24593-5mg5mg£850.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T24593-50mg50mg£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T24593-100mg100mg£2,079.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
PAO-PDT is a highly selective thioredoxin reductase inhibitor.
CAS:
256348-71-7
Formula:
C9H12AsNS2
Molecular Weight:
273.24
Purity:
0.98
SMILES:
Nc1ccc(cc1)[As]1SCCCS1

References

1. Fan XY, Liu YJ, Chen K, Jiang FL, Hu YJ, Liu D, Liu Y, Ge YS. Organic arsenicals target thioredoxin reductase followed by oxidative stress and mitochondrial dysfunction resulting in apoptosis. Eur J Med Chem. 2018 Jan 1;143:1090-1102. doi: 10.1016/j.ejmech.2017.05.022. Epub 2017 May 6. PubMed PMID: 29150332. 2. Liu Y, Duan D, Yao J, Zhang B, Peng S, Ma H, Song Y, Fang J. Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase. J Med Chem. 2014 Jun 26;57(12):5203-11. doi: 10.1021/jm500221p. Epub 2014 Jun 11. PubMed PMID: 24867309.