TargetMol

PDE5-IN-6c

Product Code:
 
TAR-T24605
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24605-5mg5mg£850.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T24605-50mg50mg£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T24605-100mg100mg£2,079.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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  • Further Information
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Further Information

Bioactivity:
PDE5-IN-6c is a potent and selective inhibitor of PDE5A1.
CAS:
1448419-13-3
Formula:
C23H21ClN4O2
Molecular Weight:
420.9
Purity:
0.98
SMILES:
COc1ccc(CNc2c3CN(CCc3nc3ccc(cc23)C#N)C(C)=O)cc1Cl

References

1. Fiorito J, Vendome J, Saeed F, Staniszewski A, Zhang H, Yan S, Deng SX, Arancio O, Landry DW. Identification of a Novel 1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer's Disease. J Med Chem. 2017 Nov 9;60(21):8858-8875. doi: 10.1021/acs.jmedchem.7b00979. Epub 2017 Oct 23. PubMed PMID: 28985058. 2. Sasseville M, C?t? N, Gagnon MC, Richard FJ. Up-regulation of 3'5'-cyclic guanosine monophosphate-specific phosphodiesterase in the porcine cumulus-oocyte complex affects steroidogenesis during in vitro maturation. Endocrinology. 2008 Nov;149(11):5568-76. doi: 10.1210/en.2008-0547. Epub 2008 Jul 31. PubMed PMID: 18669600. 3. Kim DK, Lee N, Lee JY, Ryu DH, Kim JS, Lee SH, Choi JY, Chang K, Kim YW, Im GJ, Choi WS, Kim TK, Ryu JH, Kim NH, Lee K. Synthesis and phosphodiesterase 5 inhibitory activity of novel phenyl ring modified sildenafil analogues. Bioorg Med Chem. 2001 Jun;9(6):1609-16. PubMed PMID: 11408180.