TargetMol

PYD-106

Product Code:
 
TAR-T24689
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24689-5mg5mg£850.00
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TAR-T24689-50mg50mg£1,661.00
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Quantity:
TAR-T24689-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
PYD-106 is a GluN2C-selective Positive Allosteric Modulator of the NMDA Receptor.
CAS:
1560894-05-4
Formula:
C25H24N2O5
Molecular Weight:
432.476
Purity:
0.98
SMILES:
COC(=O)c1ccc(cc1)C1N(CCc2c(C)[nH]c3ccccc23)C(=O)C(O)=C1C(C)=O

References

1. Kaiser TM, Kell SA, Kusumoto H, Shaulsky G, Bhattacharya S, Epplin MP, Strong KL, Miller EJ, Cox BD, Menaldino DS, Liotta DC, Traynelis SF, Burger PB. The Bioactive Protein-Ligand Conformation of GluN2C-Selective Positive Allosteric Modulators Bound to the NMDA Receptor. Mol Pharmacol. 2018 Feb;93(2):141-156. doi: 10.1124/mol.117.110940. Epub 2017 Dec 14. PubMed PMID: 29242355; PubMed Central PMCID: PMC5767683. 2. Hackos DH, Hanson JE. Diverse modes of NMDA receptor positive allosteric modulation: Mechanisms and consequences. Neuropharmacology. 2017 Jan;112(Pt A):34-45. doi: 10.1016/j.neuropharm.2016.07.037. Epub 2016 Jul 30. Review. PubMed PMID: 27484578. 3. Khatri A, Burger PB, Swanger SA, Hansen KB, Zimmerman S, Karakas E, Liotta DC, Furukawa H, Snyder JP, Traynelis SF. Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator. Mol Pharmacol. 2014 Nov;86(5):548-60. doi: 10.1124/mol.114.094516. Epub 2014 Sep 9. PubMed PMID: 25205677; PubMed Central PMCID: PMC4201136.