TargetMol

RO2468

Product Code:
 
TAR-T24719
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24719-5mg5mg£850.00
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Quantity:
TAR-T24719-50mg50mg£1,661.00
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Quantity:
TAR-T24719-100mg100mg£2,079.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
RO2468 is a potent and orally active inhibitor of the p53-MDM2.
CAS:
1360821-21-1
Formula:
C30H30Cl2FN5O4
Molecular Weight:
614.5
Purity:
0.98
SMILES:
COc1cc(ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ncc21)C(N)=O

References

1. Zhang Z, Chu XJ, Liu JJ, Ding Q, Zhang J, Bartkovitz D, Jiang N, Karnachi P, So SS, Tovar C, Filipovic ZM, Higgins B, Glenn K, Packman K, Vassilev L, Graves B. Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development. ACS Med Chem Lett. 2013 Dec 29;5(2):124-7. doi: 10.1021/ml400359z. eCollection 2014 Feb 13. PubMed PMID: 24900784; PubMed Central PMCID: PMC4027646.