TargetMol

ROR Modulator I

Product Code:
 
TAR-T24727
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24727-5mg5mg£850.00
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TAR-T24727-50mg50mg£1,661.00
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Quantity:
TAR-T24727-100mg100mg£2,079.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
ROR Modulator I is the first potent inverse agonist of the retinoid-related orphan receptor. It also has dual selectivity for RORβ and RORγt.
CAS:
1361413-10-6
Formula:
C26H20Cl2N2O4S2
Molecular Weight:
559.48
Purity:
0.98
SMILES:
CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(s2)C(=O)c2ccccc2Cl)-c2cccc(Cl)c2)cc1

References

1. Lee J, Lee S, Chung S, Park N, Son GH, An H, Jang J, Chang DJ, Suh YG, Kim K. Identification of a novel circadian clock modulator controlling BMAL1 expression through a ROR/REV-ERB-response element-dependent mechanism. Biochem Biophys Res Commun. 2016 Jan 15;469(3):580-6. doi: 10.1016/j.bbrc.2015.12.030. Epub 2015 Dec 12. PubMed PMID: 26692477. 2. Toyama H, Sato S, Shirakawa H, Komai M, Hashimoto Y, Fujii S. Altered activity profile of a tertiary silanol analog of multi-targeting nuclear receptor modulator T0901317. Bioorg Med Chem Lett. 2016 Apr 1;26(7):1817-20. doi: 10.1016/j.bmcl.2016.02.031. Epub 2016 Feb 12. PubMed PMID: 26905831. 3. Ding FM, Liao RM, Chen YQ, Xie GG, Zhang PY, Shao P, Zhang M. Upregulation of SOCS3 in lung CD4+ T cells in a mouse model of chronic PA lung infection and suppression of Th17 mediated neutrophil recruitment in exogenous SOCS3 transfer in vitro. Mol Med Rep. 2017 Jul;16(1):778-786. doi: 10.3892/mmr.2017.6630. Epub 2017 May 25. PubMed PMID: 28560450; PubMed Central PMCID: PMC5482193. 4. Astafev AA, Patel SA, Kondratov RV. Calorie restriction effects on circadian rhythms in gene expression are sex dependent. Sci Rep. 2017 Aug 29;7(1):9716. doi: 10.1038/s41598-017-09289-9. PubMed PMID: 28851928; PubMed Central PMCID: PMC5575277.