TargetMol

Sparsomycin

Product Code:
 
TAR-T24819
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24819-5mg5mg£973.00
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Further Information

Bioactivity:
Sparsomycin is an antitumor antibiotic. It also inhibits protein synthesis in the 70S and 80S ribosomal systems.
CAS:
1404-64-4
Formula:
C13H19N3O5S2
Molecular Weight:
361.43
Purity:
0.98
SMILES:
O=C(N[C@@H](CO)CS(CSC)=O)/C=C/C1=C(C)NC(NC1=O)=O

References

1. Miyauchi K, Komano J, Myint L, Futahashi Y, Urano E, Matsuda Z, Chiba T, Miura H, Sugiura W, Yamamoto N. Rapid propagation of low-fitness drug-resistant mutants of human immunodeficiency virus type 1 by a streptococcal metabolite sparsomycin. Antivir Chem Chemother. 2006;17(4):167-74. PubMed PMID: 17066895. 2. Ge X, Roux B. Absolute binding free energy calculations of sparsomycin analogs to the bacterial ribosome. J Phys Chem B. 2010 Jul 29;114(29):9525-39. doi: 10.1021/jp100579y. PubMed PMID: 20608691. 3. Li S, Cheng X, Zhou Y, Xi Z. Sparsomycin-linezolid conjugates can promote ribosomal translocation. Chembiochem. 2011 Dec 16;12(18):2801-6. doi: 10.1002/cbic.201100508. Epub 2011 Oct 28. PubMed PMID: 22038852. 4. Ge X, Roux B. Calculation of the standard binding free energy of sparsomycin to the ribosomal peptidyl-transferase P-site using molecular dynamics simulations with restraining potentials. J Mol Recognit. 2010 Mar-Apr;23(2):128-41. doi: 10.1002/jmr.996. PubMed PMID: 20151411.