TargetMol

SR14150

Product Code:
 
TAR-T24828
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24828-5mg5mg£850.00
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Quantity:
TAR-T24828-50mg50mg£1,661.00
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Quantity:
TAR-T24828-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
SR14150 is a partial agonist of high-affinity NOP receptor.
CAS:
709024-69-1
Formula:
C21H30N2O
Molecular Weight:
326.484
Purity:
0.98
SMILES:
O=C1Cc2ccccc2N1C1CCN(CC1)C1CCCCCCC1

References

1. G?nther T, Dasgupta P, Mann A, Miess E, Kliewer A, Fritzwanker S, Steinborn R, Schulz S. Targeting multiple opioid receptors - improved analgesics with reduced side effects? Br J Pharmacol. 2017 Apr 5. doi: 10.1111/bph.13809. [Epub ahead of print] Review. PubMed PMID: 28378462. 2. Khroyan TV, Polgar WE, Orduna J, Montenegro J, Jiang F, Zaveri NT, Toll L. Differential effects of nociceptin/orphanin FQ (NOP) receptor agonists in acute versus chronic pain: studies with bifunctional NOP/? receptor agonists in the sciatic nerve ligation chronic pain model in mice. J Pharmacol Exp Ther. 2011 Nov;339(2):687-93. doi: 10.1124/jpet.111.184663. Epub 2011 Aug 22. PubMed PMID: 21859931; PubMed Central PMCID: PMC3199991. 3. Toll L, Khroyan TV, Polgar WE, Jiang F, Olsen C, Zaveri NT. Comparison of the antinociceptive and antirewarding profiles of novel bifunctional nociceptin receptor/mu-opioid receptor ligands: implications for therapeutic applications. J Pharmacol Exp Ther. 2009 Dec;331(3):954-64. doi: 10.1124/jpet.109.157446. Epub 2009 Sep 22. PubMed PMID: 19773529; PubMed Central PMCID: PMC2784720. 4. Khroyan TV, Polgar WE, Orduna J, Jiang F, Olsen C, Toll L, Zaveri NT. Activity of new NOP receptor ligands in a rat peripheral mononeuropathy model: potentiation of morphine anti-allodynic activity by NOP receptor antagonists. Eur J Pharmacol. 2009 May 21;610(1-3):49-54. doi: 10.1016/j.ejphar.2009.03.019. Epub 2009 Mar 12. PubMed PMID: 19285491; PubMed Central PMCID: PMC2742704.