TargetMol

SSJ-183

Product Code:
 
TAR-T24835
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24835-5mg5mg£850.00
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TAR-T24835-50mg50mg£1,661.00
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Quantity:
TAR-T24835-100mg100mg£2,079.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
SSJ-183 is an antimalarial agent.
CAS:
1187533-34-1
Formula:
C25H22N4O
Molecular Weight:
394.478
Purity:
0.98
SMILES:
CCN(CC)c1ccc2nc3c(cc(=Nc4ccncc4)c4ccccc34)oc2c1

References

1. Mizukawa Y, Ge JF, Bakar Md A, Itoh I, Scheurer C, Wittlin S, Brun R, Matsuoka H, Ihara M. Novel synthetic route for antimalarial benzo[a]phenoxazine derivative SSJ-183 and two active metabolites. Bioorg Med Chem. 2014 Jul 15;22(14):3749-52. doi: 10.1016/j.bmc.2014.04.066. Epub 2014 May 10. PubMed PMID: 24856305. 2. Schleiferb?ck S, Scheurer C, Ihara M, Itoh I, Bathurst I, Burrows JN, Fantauzzi P, Lotharius J, Charman SA, Morizzi J, Shackleford DM, White KL, Brun R, Wittlin S. In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models. Drug Des Devel Ther. 2013 Nov 15;7:1377-84. doi: 10.2147/DDDT.S51298. eCollection 2013. PubMed PMID: 24255594; PubMed Central PMCID: PMC3832383. 3. Lu J, Arai C, Md AB, Ihara M. Plasmodium berghei proteome changes in response to SSJ-183 treatment. Bioorg Med Chem. 2011 Jul 1;19(13):4144-7. doi: 10.1016/j.bmc.2011.04.051. Epub 2011 May 11. PubMed PMID: 21622001. 4. Ge JF, Arai C, Yang M, Bakar Md A, Lu J, Ismail NS, Wittlin S, Kaiser M, Brun R, Charman SA, Nguyen T, Morizzi J, Itoh I, Ihara M. Discovery of Novel Benzo[a]phenoxazine SSJ-183 as a Drug Candidate for Malaria. ACS Med Chem Lett. 2010 Jul 12;1(7):360-4. doi: 10.1021/ml100120a. eCollection 2010 Oct 14. PubMed PMID: 24900219; PubMed Central PMCID: PMC4007839.