TargetMol

UPR-IN-17#

Product Code:
 
TAR-T24928
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24928-5mg5mg£850.00
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Quantity:
TAR-T24928-50mg50mg£1,661.00
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Quantity:
TAR-T24928-100mg100mg£2,079.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
UPR-IN-17# is an effective pan-inhibitor of the unfolded protein response.
CAS:
709621-32-9
Formula:
C23H22ClN3O3S
Molecular Weight:
455.96
Purity:
0.98
SMILES:
Clc1cc(NC(=O)COc2ccccc2)ccc1N1CCN(CC1)C(=O)c1cccs1

References

1. Chen D, Dixon BJ, Doycheva DM, Li B, Zhang Y, Hu Q, He Y, Guo Z, Nowrangi D, Flores J, Filippov V, Zhang JH, Tang J. IRE1? inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic-ischemic brain injury in rats. J Neuroinflammation. 2018 Feb 2;15(1):32. doi: 10.1186/s12974-018-1077-9. PubMed PMID: 29394934; PubMed Central PMCID: PMC5797348. 2. Le?nik S, ?krlj B, Er?en N, Bren U, Gobec S, Konc J, Jane?i? D. BoBER: web interface to the base of bioisosterically exchangeable replacements. J Cheminform. 2017 Dec 12;9(1):62. doi: 10.1186/s13321-017-0251-x. PubMed PMID: 29234984; PubMed Central PMCID: PMC5727005. 3. Tillotson J, Kedzior M, Guimar?es L, Ross AB, Peters TL, Ambrose AJ, Schmidlin CJ, Zhang DD, Costa-Lotufo LV, Rodr?guez AD, Schatz JH, Chapman E. ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A. Bioorg Med Chem Lett. 2017 Sep 1;27(17):4082-4085. doi: 10.1016/j.bmcl.2017.07.045. Epub 2017 Jul 19. PubMed PMID: 28757063; PubMed Central PMCID: PMC5593424. 4. Graner AN, Hellwinkel JE, Lencioni AM, Madsen HJ, Harland TA, Marchando P, Nguyen GJ, Wang M, Russell LM, Bemis LT, Anchordoquy TJ, Graner MW. HSP90 inhibitors in the context of heat shock and the unfolded protein response: effects on a primary canine pulmonary adenocarcinoma cell line. Int J Hyperthermia. 2016 Dec 20:1-15. doi: 10.1080/02656736.2016.1256503. [Epub ahead of print] PubMed PMID: 27829290; PubMed Central PMCID: PMC5675827.