TargetMol

Vapiprost

Product Code:
 
TAR-T24931
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T24931-5mg5mgEnquire
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Further Information

Bioactivity:
Vapiprost is an antagonist of the thromboxane receptor and a prostaglandin receptor.
CAS:
85505-64-2
Formula:
C30H39NO4
Molecular Weight:
477.645
Purity:
0.98
SMILES:
O[C@H]1C[C@H](OCc2ccc(cc2)-c2ccccc2)[C@H](CCC=C/CCC(O)=O)[C@H]1N1CCCCC1

References

1. Uematsu T, Nagashima S, Mizuno A, Hirano K, Nakashima M. Pharmacokinetic and pharmacodynamic profiles of vapiprost, a selective, long-lasting thromboxane receptor antagonist, after single and multiple oral administration to healthy volunteers. J Clin Pharmacol. 1991 Sep;31(9):815-22. PubMed PMID: 1839540. 2. Nishiyama H, Umemura K, Saniabadi AR, Takiguchi Y, Uematsu T, Nakashima M. Enhancement of thrombolytic efficacy of tissue-type plasminogen activator by adjuvants in the guinea pig thrombosis model. Eur J Pharmacol. 1994 Oct 24;264(2):191-8. PubMed PMID: 7851482. 3. Kan KK, Jones RL, Ngan MP, Rudd JA. Action of prostanoids on the emetic reflex of Suncus murinus (the house musk shrew). Eur J Pharmacol. 2003 Sep 23;477(3):247-51. PubMed PMID: 14522363. 4. Matsuzaki T, Noguchi K, Nakasone J, Uezu K, Higuchi M, Sakanashi M. Effects of the new thromboxane A2 antagonist vapiprost on isolated canine blood vessels. Arzneimittelforschung. 1992 Nov;42(11):1318-22. PubMed PMID: 1492844.