TargetMol

VUF-10497

Product Code:
 
TAR-T24951
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24951-5mg5mg£850.00
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Quantity:
TAR-T24951-50mg50mg£1,661.00
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Quantity:
TAR-T24951-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
VUF-10497 is a histamine H4 receptor inverse agonist (pKi = 7.57). VUF-10497 was found to possess anti-inflammatory properties in vivo in the rat. VUF-10497 also possesses a considerable affinity for the human histamine H1 receptor.
CAS:
1080623-12-6
Formula:
C18H20ClN5S
Molecular Weight:
373.9
Purity:
0.98
SMILES:
CN1CCN(CC1)c1nc(NCc2cccs2)c2cc(Cl)ccc2n1

References

1. Smits RA, de Esch IJ, Zuiderveld OP, Broeker J, Sansuk K, Guaita E, Coruzzi G, Adami M, Haaksma E, Leurs R. Discovery of quinazolines as histamine H4 receptor inverse agonists using a scaffold hopping approach. J Med Chem. 2008 Dec 25;51(24):7855-65. doi: 10.1021/jm800876b. PubMed PMID: 19053770.