TargetMol

(-)-Sotalol

Product Code:
 
TAR-T24955
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24955-5mg5mg£850.00
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Quantity:
TAR-T24955-50mg50mg£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T24955-100mg100mg£2,079.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
(-)-Sotalol is a non-selective competitive beta-adrenergic receptor blocker that also shows Class III antiarrhythmic properties.
CAS:
30236-31-8
Formula:
C12H20N2O3S
Molecular Weight:
272.36
Purity:
0.98
SMILES:
CC(C)NC[C@H](O)c1ccc(NS(C)(=O)=O)cc1

References

1. Darpo B, Karnad DR, Badilini F, Florian J, Garnett CE, Kothari S, Panicker GK, Sarapa N. Are women more susceptible than men to drug-induced QT prolongation? Concentration-QTc modelling in a phase 1 study with oral rac-sotalol. Br J Clin Pharmacol. 2014 Mar;77(3):522-31. doi: 10.1111/bcp.12201. PubMed PMID: 23819796; PubMed Central PMCID: PMC4371537. 2. Feiner M, Laforsch C, Letzel T, Geist J. Sublethal effects of the beta-blocker sotalol at environmentally relevant concentrations on the New Zealand mudsnail Potamopyrgus antipodarum. Environ Toxicol Chem. 2014 Nov;33(11):2510-5. doi: 10.1002/etc.2699. Epub 2014 Aug 28. PubMed PMID: 25132045. 3. Rivolta MW, Mainardi LT, Sassi R. Quantification of ventricular repolarization heterogeneity during moxifloxacin or sotalol administration using [Formula: see text]-index. Physiol Meas. 2015 Apr;36(4):803-11. doi: 10.1088/0967-3334/36/4/803. Epub 2015 Mar 23. PubMed PMID: 25798997. 4. Somberg JC, Preston RA, Ranade V, Cvetanovic I, Molnar J. Gender differences in cardiac repolarization following intravenous sotalol administration. J Cardiovasc Pharmacol Ther. 2012 Mar;17(1):86-92. doi: 10.1177/1074248411406505. Epub 2011 Apr 28. PubMed PMID: 21527783.