TargetMol

10-Methyl-10-deazaaminopterin

Product Code:
 
TAR-T24963
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T24963-5mg5mg£850.00
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TAR-T24963-50mg50mg£1,661.00
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TAR-T24963-100mg100mg£2,079.00
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Further Information

Bioactivity:
10-Methyl-10-deazaaminopterin is a folate analog that shows antitumor activity.
CAS:
80576-77-8
Formula:
C21H23N7O5
Molecular Weight:
453.459
Purity:
0.98
SMILES:
CC(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O

References

1. DeGraw JI, Christie PH, Tagawa H, Kisliuk RL, Gaumont Y, Schmid FA, Sirotnak FM. Synthesis and biological activity of resolved C-10 diastereomers of 10-methyl- and 10-ethyl-10-deazaminopterin. J Med Chem. 1986 Jun;29(6):1056-61. PubMed PMID: 3712374. 2. Sirotnak FM, DeGraw JI, Schmid FA, Goutas LJ, Moccio DM. New folate analogs of the 10-deaza-aminopterin series. Further evidence for markedly increased antitumor efficacy compared with methotrexate in ascitic and solid murine tumor models. Cancer Chemother Pharmacol. 1984;12(1):26-30. PubMed PMID: 6690070. 3. Sirotnak FM, DeGraw JI, Moccio DM, Samuels LL, Goutas LJ. New folate analogs of the 10-deaza-aminopterin series. Basis for structural design and biochemical and pharmacologic properties. Cancer Chemother Pharmacol. 1984;12(1):18-25. PubMed PMID: 6690069.