TargetMol

NSC 74859

Product Code:
 
TAR-T2505
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2505-1mL1 mL * 10 mM (in DMSO)£111.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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TAR-T2505-5mg5mg£111.00
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TAR-T2505-10mg10mg£121.00
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TAR-T2505-25mg25mg£149.00
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TAR-T2505-50mg50mg£192.00
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Quantity:
TAR-T2505-100mg100mg£295.00
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Quantity:
TAR-T2505-200mg200mg£409.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
S3I-201 is a selective Stat3 inhibitor (IC50: 86?33 μM) and low effect towards STAT1/5.
CAS:
501919-59-1
Formula:
C16H15NO7S
Molecular Weight:
365.36
Pathway:
JAK/STAT signaling; Stem Cells
Purity:
0.9905
SMILES:
Cc1ccc(cc1)S(=O)(=O)OCC(=O)Nc1ccc(C(O)=O)c(O)c1
Target:
STAT

References

1. Siddiquee K, et al. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7391-6. 2. Zhang S, et al. Trp53 negatively regulates autoimmunity via the STAT3-Th17 axis. FASEB J. 2011 Jul;25(7):2387-98. 3. Chen W, et al. NSC 74859-mediated inhibition of STAT3 enhances the anti-proliferative activity of cetuximab in hepatocellular carcinoma. Liver Int. 2012 Jan;32(1):70-7. 4. Zhou C, et al. STAT3 upregulation in pituitary somatotroph adenomas induces growth hormone hypersecretion. J Clin Invest. 2015 Apr;125(4):1692-702 5. Chen X J, He M J, Zhou G. All?trans retinoic acid induces anti?tumor effects via STAT 3 signaling inhibition in oral squamous cell carcinoma and oral dysplasia[J]. Journal of Oral Pathology & Medicine. 2019.