TargetMol

CH5447240

Product Code:
 
TAR-T25234
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25234-5mg5mg£1,412.00
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TAR-T25234-50mg50mg£2,785.00
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Quantity:
TAR-T25234-100mg100mg£3,765.00
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This product comes from: United States.
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Further Information

Bioactivity:
CH5447240 is an effective Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist for the treatment of Hypoparathyroidism. CH5447240 showed a potent in vitro hPTHR1 agonist effect (EC20: 3.0 nM; EC50: 12 nM). It showed 55% oral bioavailability and a significantly elevated serum calcium level in hypocalcemic model rats.
CAS:
1253919-92-4
Formula:
C26H39N5O4S
Molecular Weight:
517.69
Purity:
0.98
SMILES:
C[C@H]1CC[C@@H](CC1)C1=NC2(CCN(CC2)S(=O)(=O)CCc2c(C)cc(cc2C)N(C)C(N)=O)C(=O)N1

References

1. Nishimura Y, Esaki T, Isshiki Y, Okamoto N, Furuta Y, Kotake T, Watanabe Y, Ohta M, Nakagawa T, Noda H, Shimizu M, Saito H, Tamura T, Sato H. Development of a Novel Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist (CH5447240), a Potent and Orally Available Small-Molecule for Treatment of Hypoparathyroidism. J Med Chem. 2018 Jun 22. doi: 10.1021/acs.jmedchem.8b00182. [Epub ahead of print] PubMed PMID: 29932656.