TargetMol

CHD-5

Product Code:
 
TAR-T25235
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25235-5mg5mg£304.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T25235-50mg50mg£1,026.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T25235-100mg100mg£1,524.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
CHD-5 is a selective antagonist of the aryl hydrocarbon receptor (AhR).
CAS:
289494-16-2
Formula:
C19H17N3O2
Molecular Weight:
319.364
Purity:
0.98
SMILES:
Cc1ccccc1N=Nc1ccc(NC(=O)c2ccco2)c(C)c1

References

1. Higashi M, Kolla V, Iyer R, Naraparaju K, Zhuang T, Kolla S, Brodeur GM. Retinoic acid-induced CHD5 upregulation and neuronal differentiation of neuroblastoma. Mol Cancer. 2015 Aug 7;14:150. doi: 10.1186/s12943-015-0425-y. PubMed PMID: 26245651; PubMed Central PMCID: PMC4527355. 2. Kolla V, Zhuang T, Higashi M, Naraparaju K, Brodeur GM. Role of CHD5 in human cancers: 10 years later. Cancer Res. 2014 Feb 1;74(3):652-8. doi: 10.1158/0008-5472.CAN-13-3056. Epub 2014 Jan 13. Review. PubMed PMID: 24419087; PubMed Central PMCID: PMC3965582. 3. Kolla V, Naraparaju K, Zhuang T, Higashi M, Kolla S, Blobel GA, Brodeur GM. The tumour suppressor CHD5 forms a NuRD-type chromatin remodelling complex. Biochem J. 2015 Jun 1;468(2):345-52. doi: 10.1042/BJ20150030. PubMed PMID: 25825869; PubMed Central PMCID: PMC4487910. 4. Bishop B, Ho KK, Tyler K, Smith A, Bonilla S, Leung YF, Ogas J. The chromatin remodeler chd5 is necessary for proper head development during embryogenesis of Danio rerio. Biochim Biophys Acta. 2015 Aug;1849(8):1040-50. doi: 10.1016/j.bbagrm.2015.06.006. Epub 2015 Jun 17. PubMed PMID: 26092436; PubMed Central PMCID: PMC4544782.