TargetMol

Crambene

Product Code:
 
TAR-T25275
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25275-5mg5mg£850.00
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TAR-T25275-50mg50mg£1,661.00
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Quantity:
TAR-T25275-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Crambene results in the induction of apoptosis by protects mice against acute pancreatitis via anti-inflammatory pathways.
CAS:
6071-81-4
Formula:
C5H7NO
Molecular Weight:
97.117
Purity:
0.98
SMILES:
O[C@@H](CC#N)C=C

References

1. Cao Y, Adhikari S, Cl?ment MV, Wallig M, Bhatia M. Induction of apoptosis by crambene protects mice against acute pancreatitis via anti-inflammatory pathways. Am J Pathol. 2007 May;170(5):1521-34. PubMed PMID: 17456759; PubMed Central PMCID: PMC1854948. 2. Cao Y, Adhikari S, Ang AD, Cl?ment MV, Wallig M, Bhatia M. Crambene induces pancreatic acinar cell apoptosis via the activation of mitochondrial pathway. Am J Physiol Gastrointest Liver Physiol. 2006 Jul;291(1):G95-G101. Epub 2006 Apr 6. PubMed PMID: 16603484. 3. Nho CW, Jeffery E. Crambene, a bioactive nitrile derived from glucosinolate hydrolysis, acts via the antioxidant response element to upregulate quinone reductase alone or synergistically with indole-3-carbinol. Toxicol Appl Pharmacol. 2004 Jul 1;198(1):40-8. PubMed PMID: 15207647. 4. Keck AS, Staack R, Jeffery EH. The cruciferous nitrile crambene has bioactivity similar to sulforaphane when administered to Fischer 344 rats but is far less potent in cell culture. Nutr Cancer. 2002;42(2):233-40. PubMed PMID: 12416265.