TargetMol

ES 8891

Product Code:
 
TAR-T25387
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25387-5mg5mg£1,171.00
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TAR-T25387-50mg50mg£2,303.00
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Quantity:
TAR-T25387-100mg100mg£3,042.00
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This product comes from: United States.
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Further Information

Bioactivity:
ES 8891 is an inhibitor of renin.
CAS:
129445-88-1
Formula:
C42H60N6O6S
Molecular Weight:
777.04
Purity:
0.98
SMILES:
CCCCCCNC(=O)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1cscn1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)CN1CCOCC1

References

1. Ii Y, Murakami E, Hiwada K. Effect of renin inhibitor, ES-8891, on renal renin secretion and storage in the marmoset: comparison with captopril. J Hypertens. 1991 Dec;9(12):1119-25. PubMed PMID: 1663967. 2. Kokubu T, Hiwada K, Murakami E, Muneta S, Kitami Y, Salmon PF. ES-8891, an orally active inhibitor of human renin. Hypertension. 1990 Jun;15(6 Pt 2):909-13. PubMed PMID: 2112512. 3. Kitami Y, Hiwada K, Murakami E, Iwata T, Muneta S, Kokubu T. Kidney renin gene expression after renin inhibition in the marmoset. Clin Sci (Lond). 1991 Sep;81(3):387-92. PubMed PMID: 1655341. 4. Fukamizu A, Sugimura K, Takimoto E, Sugiyama F, Seo MS, Takahashi S, Hatae T, Kajiwara N, Yagami K, Murakami K. Chimeric renin-angiotensin system demonstrates sustained increase in blood pressure of transgenic mice carrying both human renin and human angiotensinogen genes. J Biol Chem. 1993 Jun 5;268(16):11617-21. PubMed PMID: 8505294.