TargetMol

FAUC-113

Product Code:
 
TAR-T25407
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T25407-5mg5mg£850.00
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TAR-T25407-50mg50mg£1,661.00
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TAR-T25407-100mg100mg£2,079.00
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Further Information

Bioactivity:
FAUC-113 is an antagonist of Dopamine D4 receptor.
CAS:
221470-50-4
Formula:
C18H19ClN4
Molecular Weight:
326.83
Purity:
0.98
SMILES:
Clc1ccc(cc1)N1CCN(Cc2cnn3ccccc23)CC1

References

1. Lanig H, Utz W, Gmeiner P. Comparative molecular field analysis of dopamine D4 receptor antagonists including 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 113), 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]-1H-pyrrolo-[2,3-b]pyridine (L-745,870), and clozapine. J Med Chem. 2001 Apr 12;44(8):1151-7. PubMed PMID: 11312915. 2. Prante O, Hocke C, L?ber S, H?bner H, Gmeiner P, Kuwert T. Tissue distribution of radioiodinated FAUC113: assessment of a pyrazolo(1,5-a) pyridine based dopamine D4 receptor radioligand candidate. Nuklearmedizin. 2006;45(1):41-8. PubMed PMID: 16493513. 3. L?ber S, Aboul-Fadl T, H?bner H, Gmeiner P. Di- and trisubstituted pyrazolo[1,5-a]pyridine derivatives: synthesis, dopamine receptor binding and ligand efficacy. Bioorg Med Chem Lett. 2002 Feb 25;12(4):633-6. PubMed PMID: 11844688. 4. Feng Z, Hou T, Li Y. Structure-based drug design for dopamine D3 receptor. Comb Chem High Throughput Screen. 2012 Dec;15(10):775-91. PubMed PMID: 22931309.