TargetMol

FK 224

Product Code:
 
TAR-T25419
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T25419-5mg5mg£850.00
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Further Information

Bioactivity:
FK 224 is an antagonist of tachykinin receptor.
CAS:
125787-94-2
Formula:
C54H72N8O13
Molecular Weight:
1041.213
Purity:
0.98
SMILES:
CCCCCc1ccccc1CCC(=O)N[C@H]1[C@@H](C)OC(=O)[C@H](CO)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)NC(=O)C(=Cc2ccc(O)cc2)N(C)C1=O)[C@H](C)O

References

1. Morimoto H, Murai M, Maeda Y, Yamaoka M, Nishikawa M, Kiyotoh S, Fujii T. FK 224, a novel cyclopeptide substance P antagonist with NK1 and NK2 receptor selectivity. J Pharmacol Exp Ther. 1992 Jul;262(1):398-402. PubMed PMID: 1378096. 2. Aizawa H, Koto H, Nakano H, Inoue H, Matsumoto K, Takata S, Shigyo M, Hara N. The effects of a specific tachykinin receptor antagonist FK-224 on ozone-induced airway hyperresponsiveness and inflammation. Respirology. 1997 Dec;2(4):261-5. PubMed PMID: 9525295. 3. Schmidt D, J?rres RA, Rabe KF, Magnussen H. Reproducibility of airway response to inhaled bradykinin and effect of the neurokinin receptor antagonist FK-224 in asthmatic subjects. Eur J Clin Pharmacol. 1996;50(4):269-73. PubMed PMID: 8803517. 4. Morimoto H, Yamashita M, Matsuda A, Miyake H, Fujii T. Effects of FR 113680 and FK 224, novel tachykinin receptor antagonists, on cigarette smoke-induced rat tracheal plasma extravasation. Eur J Pharmacol. 1992 Nov 24;224(1):1-5. PubMed PMID: 1280594.