TargetMol

GS-9191

Product Code:
 
TAR-T25466
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25466-1mg1mg£215.00
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TAR-T25466-5mg5mg£432.00
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TAR-T25466-1mL1 mL * 10 mM (in DMSO)£595.00
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TAR-T25466-10mg10mg£603.00
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TAR-T25466-25mg25mg£863.00
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TAR-T25466-50mg50mg£1,187.00
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TAR-T25466-100mg100mg£1,581.00
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TAR-T25466-500mg500mg£3,115.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
GS-9191 is a novel antipapillomavirus drug.
CAS:
859209-84-0
Formula:
C37H51N8O5P
Molecular Weight:
718.84
Pathway:
DNA Damage/DNA Repair|Cell Cycle/Checkpoint
Purity:
0.98
SMILES:
CC(C)COC(=O)[C@H](Cc1ccccc1)NP(COCCn1cnc2c(NC3CC3)nc(N)nc12)N[C@@H](Cc1ccccc1)C(=O)OCC(C)C
Target:
DNA/RNA Synthesis

References

1. Birkus G, Kutty N, Frey CR, Shribata R, Chou T, Wagner C, McDermott M, Cihlar T. Role of cathepsin A and lysosomes in the intracellular activation of novel antipapillomavirus agent GS-9191. Antimicrob Agents Chemother. 2011 May;55(5):2166-73. doi: 10.1128/AAC.01603-10. Epub 2011 Mar 7. PubMed PMID: 21383096; PubMed Central PMCID: PMC3088193. 2. Wolfgang GH, Shibata R, Wang J, Ray AS, Wu S, Doerrfler E, Reiser H, Lee WA, Birkus G, Christensen ND, Andrei G, Snoeck R. GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. Antimicrob Agents Chemother. 2009 Jul;53(7):2777-84. doi: 10.1128/AAC.00103-09. Epub 2009 Apr 27. PubMed PMID: 19398642; PubMed Central PMCID: PMC2704673. 3. De Clercq E. Dancing with chemical formulae of antivirals: a personal account. Biochem Pharmacol. 2013 Sep 15;86(6):711-25. doi: 10.1016/j.bcp.2013.07.012. Epub 2013 Jul 19. Review. PubMed PMID: 23876344. 4. Rai MA, Pannek S, Fichtenbaum CJ. Emerging reverse transcriptase inhibitors for HIV-1 infection. Expert Opin Emerg Drugs. 2018 Jun;23(2):149-157. doi: 10.1080/14728214.2018.1474202. Epub 2018 May 10. PubMed PMID: 29737220.