TargetMol

KBH-A42

Product Code:
 
TAR-T25566
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25566-5mg5mg£850.00
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Quantity:
TAR-T25566-50mg50mg£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T25566-100mg100mg£2,079.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
KBH-A42 is an inhibitor of histone deacetylase.
CAS:
798543-50-7
Formula:
C17H22N2O3
Molecular Weight:
302.374
Purity:
0.98
SMILES:
ONC(=O)CCC1=CCCN(CCCc2ccccc2)C1=O

References

1. Kang MR, Kang JS, Yang JW, Kim BG, Kim JA, Jo YN, Lee K, Lee CW, Lee KH, Yun J, Kim HM, Han G, Kang JS, Park SK. Gene expression profiling of KBH-A42, a novel histone deacetylase inhibitor, in human leukemia and bladder cancer cell lines. Oncol Lett. 2012 Jan;3(1):113-118. Epub 2011 Sep 28. PubMed PMID: 22740865; PubMed Central PMCID: PMC3362651. 2. Kang MR, Lee K, Kang JS, Lee CW, Lee KH, Kim JH, Yang JW, Kim BG, Han G, Kang JS, Park SK, Kim HM. KBH-A42, a histone deacetylase inhibitor, inhibits the growth of doxorubicin-resistant leukemia cells expressing P-glycoprotein. Oncol Rep. 2010 Mar;23(3):801-9. PubMed PMID: 20127023. 3. Kang MR, Kang JS, Han SB, Kim JH, Kim DM, Lee K, Lee CW, Lee KH, Lee CH, Han G, Kang JS, Kim HM, Park SK. A novel delta-lactam-based histone deacetylase inhibitor, KBH-A42, induces cell cycle arrest and apoptosis in colon cancer cells. Biochem Pharmacol. 2009 Sep 1;78(5):486-94. doi: 10.1016/j.bcp.2009.05.010. Epub 2009 May 13. PubMed PMID: 19445901. 4. Choi Y, Park SK, Kim HM, Kang JS, Yoon YD, Han SB, Han JW, Yang JS, Han G. Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model. Exp Mol Med. 2008 Oct 31;40(5):574-81. PubMed PMID: 18985016; PubMed Central PMCID: PMC2679350.