TargetMol

LB-30057

Product Code:
 
TAR-T25646
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25646-5mg5mg£930.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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TAR-T25646-50mg50mg£1,821.00
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Quantity:
TAR-T25646-100mg100mg£2,319.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
LB-30057 is used as an oral thrombin inhibitor.
CAS:
184770-78-3
Formula:
C26H31N5O3S
Molecular Weight:
493.63
Purity:
0.98
SMILES:
NNC(=N)c1ccc(C[C@H](NS(=O)(=O)c2ccc3ccccc3c2)C(=O)NCC2CCCC2)cc1

References

1. Stern R, Chanoine F, Criswell K. Are coagulation times biomarkers? Data from a phase I study of the oral thrombin inhibitor LB-30057 (CI-1028). J Clin Pharmacol. 2003 Feb;43(2):118-21. PubMed PMID: 12616662. 2. Chi L, Mertz TE, Rogers KL, Janiczek N, Peng YW, Saganek L, Bousley RF, Juneau PL, Uprichard AC, Gallagher KP. Antithrombotic effect of LB-30057 (CI-1028), a new synthetic thrombin inhibitor, in a rabbit model of thrombosis: comparison with inogatran. J Thromb Thrombolysis. 2001 Feb;11(1):19-31. PubMed PMID: 11248787. 3. Oh YS, Yun M, Hwang SY, Hong S, Shin Y, Lee K, Yoon KH, Yoo YJ, Kim DS, Lee SH, Lee YH, Park HD, Lee CH, Lee SK, Kim S. Discovery of LB30057, a benzamidrazone-based selective oral thrombin inhibitor. Bioorg Med Chem Lett. 1998 Mar 17;8(6):631-4. PubMed PMID: 9871573. 4. Jung BI, Kang KT, Bae ON, Lee MY, Chung SM, Lee SK, Kim IC, Chung JH. LB30057 inhibits platelet aggregation and vascular relaxation induced by thrombin. Arch Pharm Res. 2002 Dec;25(6):879-84. PubMed PMID: 12510842.