TargetMol

L-NIL dihydrochloride

Product Code:
 
TAR-T25749
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25749-5mg5mg£850.00
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TAR-T25749-50mg50mg£1,661.00
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Quantity:
TAR-T25749-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
L-NIL HCl is a relatively selective iNOS inhibitor (IC50s: 0.4-3.3, 8-38, and 17-92 ?M for iNOS, eNOS, and nNOS). L-NIL effectively inhibits iNOS both in vitro and in vivo. L-NIL has been used to demonstrate a critical role for iNOS in the immune response to infection by the protozoan L. major.
CAS:
159190-45-1
Formula:
C8H19Cl2N3O2
Molecular Weight:
260.16
Purity:
0.98
SMILES:
Cl.Cl.NCCCC[C@H](NCC=N)C(O)=O

References

1. Lu G, Zhang R, Geng S, Peng L, Jayaraman P, Chen C, Xu F, Yang J, Li Q, Zheng H, Shen K, Wang J, Liu X, Wang W, Zheng Z, Qi CF, Si C, He JC, Liu K, Lira SA, Sikora AG, Li L, Xiong H. Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization. Nat Commun. 2015 Mar 27;6:6676. doi: 10.1038/ncomms7676. PubMed PMID: 25813085; PubMed Central PMCID: PMC4389243. 2. Tong J, Wang Y, Chang B, Zhang D, Liu P, Wang B. Activation of RhoA in alcohol-induced intestinal barrier dysfunction. Inflammation. 2013 Jun;36(3):750-8. doi: 10.1007/s10753-013-9601-7. PubMed PMID: 23361851. 3. Sinha BK, Kumar A, Bhattacharjee S, Espey MG, Mason RP. Effect of nitric oxide on the anticancer activity of the topoisomerase-active drugs etoposide and adriamycin in human melanoma cells. J Pharmacol Exp Ther. 2013 Dec;347(3):607-14. doi: 10.1124/jpet.113.207928. Epub 2013 Sep 18. PubMed PMID: 24049059; PubMed Central PMCID: PMC3836306. 4. Lendeckel U, Wolke C, Bernstein HG, Keilhoff G. Effects of nitric oxide synthase deficiency on a disintegrin and metalloproteinase domain-containing protein 12 expression in mouse brain samples. Mol Med Rep. 2015 Aug;12(2):2253-62. doi: 10.3892/mmr.2015.3643. Epub 2015 Apr 17. PubMed PMID: 25892053.