TargetMol

Loperamide oxide

Product Code:
 
TAR-T25753
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25753-5mg5mg£850.00
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TAR-T25753-50mg50mg£1,661.00
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TAR-T25753-100mg100mg£2,079.00
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Further Information

Bioactivity:
Loperamide oxide is a prodrug of loperamide, the effective antidiarrheal.
CAS:
106900-12-3
Formula:
C29H33ClN2O3
Molecular Weight:
493.04
Purity:
0.98
SMILES:
CN(C)C(=O)C(CC[N@+]1([O-])CC[C@](O)(CC1)c1ccc(Cl)cc1)(c1ccccc1)c1ccccc1

References

1. Kamali F, Huang ML. Increased systemic availability of loperamide after oral administration of loperamide and loperamide oxide with cotrimoxazole. Br J Clin Pharmacol. 1996 Feb;41(2):125-8. PubMed PMID: 8838438. 2. Dettmer A. Loperamide oxide in the treatment of acute diarrhea in adults. Clin Ther. 1994 Nov-Dec;16(6):972-80. PubMed PMID: 7697694. 3. Stacher G, Steinringer H, Schneider C, Vacariu-Granser GV, Castiglione F, Gaupmann G, Weber U, Stacher-Janotta G. Effects of the prodrug loperamide oxide, loperamide, and placebo on jejunal motor activity. Dig Dis Sci. 1992 Feb;37(2):198-204. PubMed PMID: 1735336. 4. Dreverman JW, Van der Poel AJ. Loperamide oxide in acute diarrhoea: a double-blind, placebo-controlled trial. The Dutch Diarrhoea Trialists Group. Aliment Pharmacol Ther. 1995 Aug;9(4):441-6. PubMed PMID: 8527621.