TargetMol

Lu AF58801

Product Code:
 
TAR-T25760
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25760-5mg5mg£850.00
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Quantity:
TAR-T25760-50mg50mg£1,661.00
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Quantity:
TAR-T25760-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Lu AF58801 is a brain penetrant positive allosteric and selective modulator of alpha-7 nicotinic acetylcholine receptors.
CAS:
1531592-40-1
Formula:
C20H23NO3
Molecular Weight:
325.408
Purity:
0.98
SMILES:
CCOc1ccc(cc1)[C@H](CO)NC(=O)[C@H]1C[C@@H]1c1ccccc1

References

1. Gass N, Weber-Fahr W, Sartorius A, Becker R, Didriksen M, Stensb?l TB, Bastlund JF, Meyer-Lindenberg A, Schwarz AJ. An acetylcholine alpha7 positive allosteric modulator rescues a schizophrenia-associated brain endophenotype in the 15q13.3 microdeletion, encompassing CHRNA7. Eur Neuropsychopharmacol. 2016 Jul;26(7):1150-60. doi: 10.1016/j.euroneuro.2016.03.013. Epub 2016 Mar 28. PubMed PMID: 27061851. 2. Eskildsen J, Redrobe JP, Sams AG, Dekermendjian K, Laursen M, Boll JB, Papke RL, Bundgaard C, Frederiksen K, Bastlund JF. Discovery and optimization of Lu AF58801, a novel, selective and brain penetrant positive allosteric modulator of alpha-7 nicotinic acetylcholine receptors: attenuation of subchronic phencyclidine (PCP)-induced cognitive deficits in rats following oral administration. Bioorg Med Chem Lett. 2014 Jan 1;24(1):288-93. doi: 10.1016/j.bmcl.2013.11.022. Epub 2013 Nov 20. PubMed PMID: 24291041.