TargetMol

Me-Indoxam

Product Code:
 
TAR-T25787
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1

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CodeSizePrice
TAR-T25787-5mg5mg£1,010.00
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TAR-T25787-50mg50mg£1,982.00
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Quantity:
TAR-T25787-100mg100mg£2,560.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Me-Indoxam is an inhibitor of sPLA2. It has no effect on arachidonic acid release and platelet activating factor synthesis.
CAS:
172732-62-6
Formula:
C26H22N2O5
Molecular Weight:
442.471
Purity:
0.98
SMILES:
Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1-c1ccccc1

References

1. Granata F, Frattini A, Loffredo S, Staiano RI, Petraroli A, Ribatti D, Oslund R, Gelb MH, Lambeau G, Marone G, Triggiani M. Production of vascular endothelial growth factors from human lung macrophages induced by group IIA and group X secreted phospholipases A2. J Immunol. 2010 May 1;184(9):5232-41. doi: 10.4049/jimmunol.0902501. Epub 2010 Mar 31. PubMed PMID: 20357262; PubMed Central PMCID: PMC3073479. 2. Triggiani M, Giannattasio G, Calabrese C, Loffredo S, Granata F, Fiorello A, Santini M, Gelb MH, Marone G. Lung mast cells are a source of secreted phospholipases A2. J Allergy Clin Immunol. 2009 Sep;124(3):558-65, 565.e1-3. doi: 10.1016/j.jaci.2009.04.035. Epub 2009 Jul 9. PubMed PMID: 19541351; PubMed Central PMCID: PMC2788562. 3. Giannattasio G, Lai Y, Granata F, Mounier CM, Nallan L, Oslund R, Leslie CC, Marone G, Lambeau G, Gelb MH, Triggiani M. Expression of phospholipases A2 in primary human lung macrophages: role of cytosolic phospholipase A2-alpha in arachidonic acid release and platelet activating factor synthesis. Biochim Biophys Acta. 2009 Feb;1791(2):92-102. doi: 10.1016/j.bbalip.2008.12.002. Epub 2008 Dec 16. PubMed PMID: 19130898; PubMed Central PMCID: PMC2676353. 4. Touaibia M, Djimd? A, Cao F, Boilard E, Bezzine S, Lambeau G, Redeuilh C, Lamouri A, Massicot F, Chau F, Dong CZ, Heymans F. Inhibition of secreted phospholipase A2. 4-glycerol derivatives of 4,5-dihydro-3-(4-tetradecyloxybenzyl)-1,2,4-4H-oxadiazol-5-one with broad activities. J Med Chem. 2007 Apr 5;50(7):1618-26. Epub 2007 Mar 3. PubMed PMID: 17335183.