TargetMol

ML350

Product Code:
 
TAR-T25819
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25819-5mg5mg£850.00
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Quantity:
TAR-T25819-50mg50mg£1,661.00
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Quantity:
TAR-T25819-100mg100mg£2,079.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
ML350 (CYM-50202) is a KOR (IC50: 12.6 nM) antagonist with good and moderate selectivity against the DOR and MOR. CYM-50202 displayed high solubility and excellent CNS penetration. CYM-50202 did not display long-lasting pharmacodynamic effects observed with prototypical KOR antagonists.
CAS:
1565852-90-5
Formula:
C18H26BrN3O3
Molecular Weight:
412.328
Purity:
0.98
SMILES:
COC(=O)c1cc(Br)cnc1N1CC[C@H](NC2CCCCC2)[C@@H](O)C1

References

1. Guerrero M, Urbano M, Brown SJ, Cayanan C, Ferguson J, Cameron M, Devi LA, Roberts E, Rosen H. Optimization and characterization of an opioid kappa receptor (OPRK1) antagonist. 2013 Apr 15 [updated 2014 Sep 18]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK179827/ PubMed PMID: 24479196.