TargetMol

Monactin

Product Code:
 
TAR-T25827
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T25827-5mg5mg£1,771.00
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Further Information

Bioactivity:
Monactin is a Marcrotetrolide antibiotic produced by cycloheximide producing species of Streptomyces. It is a homolog of nonactin from the same species.
CAS:
7182-54-9
Formula:
C41H66O12
Molecular Weight:
750.967
Purity:
0.98
SMILES:
CC[C@H]1C[C@@H]2CC[C@H](O2)[C@@H](C)C(=O)O[C@@H](C)C[C@@H]2CC[C@@H](O2)[C@H](C)C(=O)O[C@@H](C)C[C@@H]2CC[C@H](O2)[C@H](C)C(=O)O[C@@H](C)C[C@@H]2CC[C@H](O2)[C@H](C)C(=O)O1

References

1. Islam MT, Laatsch H, von Tiedemann A. Inhibitory Effects of Macrotetrolides from Streptomyces spp. On Zoosporogenesis and Motility of Peronosporomycete Zoospores Are Likely Linked with Enhanced ATPase Activity in Mitochondria. Front Microbiol. 2016 Nov 18;7:1824. eCollection 2016. PubMed PMID: 27917156; PubMed Central PMCID: PMC5114239. 2. Shishlyannikova TA, Kuzmin AV, Fedorova GA, Shishlyannikov SM, Lipko IA, Sukhanova EV, Belkova NL. Ionofore antibiotic polynactin produced by Streptomyces sp. 156A isolated from Lake Baikal. Nat Prod Res. 2017 Mar;31(6):639-644. doi: 10.1080/14786419.2016.1217203. Epub 2016 Aug 3. PubMed PMID: 27486824. 3. Harinantenaina Rakotondraibe L, Rasolomampianina R, Park HY, Li J, Slebodnik C, Brodie PJ, Blasiak LC, Hill R, TenDyke K, Shen Y, Cassera MB, Rejo F, Kingston DG. Antiproliferative and antiplasmodial compounds from selected Streptomyces species. Bioorg Med Chem Lett. 2015 Dec 1;25(23):5646-9. doi: 10.1016/j.bmcl.2015.07.103. Epub 2015 Aug 6. PubMed PMID: 26508548; PubMed Central PMCID: PMC4636933. 4. Crevelin EJ, Crotti AE, Zucchi TD, Melo IS, Moraes LA. Dereplication of Streptomyces sp. AMC 23 polyether ionophore antibiotics by accurate-mass electrospray tandem mass spectrometry. J Mass Spectrom. 2014 Nov;49(11):1117-26. doi: 10.1002/jms.3432. PubMed PMID: 25395127.