TargetMol

NC182

Product Code:
 
TAR-T25856
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25856-5mg5mg£850.00
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TAR-T25856-50mg50mg£1,661.00
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Quantity:
TAR-T25856-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
NC182 is a topo II inhibitor that shows selective and potent topo II inhibition on the induction of topo II-dependent DNA fragmentation.
CAS:
106224-67-3
Formula:
C24H24N4O5
Molecular Weight:
448.479
Purity:
0.98
SMILES:
COC(=O)c1cc2nc3c(C(=O)NCCN(C)C)c(O)c4ccccc4c3nc2cc1OC

References

1. Apostolova LG, Hwang KS, Kohannim O, Avila D, Elashoff D, Jack CR Jr, Shaw L, Trojanowski JQ, Weiner MW, Thompson PM; Alzheimer's Disease Neuroimaging Initiative. ApoE4 effects on automated diagnostic classifiers for mild cognitive impairment and Alzheimer's disease. Neuroimage Clin. 2014 Jan 4;4:461-72. doi: 10.1016/j.nicl.2013.12.012. eCollection 2014. PubMed PMID: 24634832; PubMed Central PMCID: PMC3952354. 2. Moorthy NS, Pratheepa V, Ramos MJ, Vasconcelos V, Fernandes PA. Fused aryl-phenazines: scaffold for the development of bioactive molecules. Curr Drug Targets. 2014;15(7):681-8. Review. PubMed PMID: 24499398. 3. Tarui M, Doi M, Ishida T, Inoue M, Nakaike S, Kitamura K. DNA-binding characterization of a novel anti-tumour benzo[a]phenazine derivative NC-182: spectroscopic and viscometric studies. Biochem J. 1994 Nov 15;304 ( Pt 1):271-9. PubMed PMID: 7998945; PubMed Central PMCID: PMC1137482.