TargetMol

Nocardicin A

Product Code:
 
TAR-T25876
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T25876-5mg5mg£850.00
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Further Information

Bioactivity:
Nocardicin A, a moderate antibiotic agent, shows inhibitory for a wild spectrum of gram-negative bacteria.
CAS:
39391-39-4
Formula:
C23H24N4O9
Molecular Weight:
500.464
Purity:
0.98
SMILES:
N[C@H](CCOc1ccc(cc1)C(=NO)C(=O)N[C@H]1CN([C@@H](C(O)=O)c2ccc(O)cc2)C1=O)C(O)=O

References

1. Decuyper L, Deketelaere S, Vanparys L, Jukic M, Sosic I, Sauvage E, Amoroso AM, Verlaine O, Joris B, Gobec S, D'hooghe M. In silico design and enantioselective synthesis of functionalized monocyclic 3-amino-1-carboxymethyl-?-lactams as inhibitors of penicillin-binding proteins of resistant bacteria. Chemistry. 2018 Jun 8. doi: 10.1002/chem.201801868. [Epub ahead of print] PubMed PMID: 29882610. 2. Gaudelli NM, Long DH, Townsend CA. ?-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis. Nature. 2015 Apr 16;520(7547):383-7. doi: 10.1038/nature14100. Epub 2015 Jan 26. PubMed PMID: 25624104; PubMed Central PMCID: PMC4401618. 3. Gaudelli NM, Townsend CA. Epimerization and substrate gating by a TE domain in ?-lactam antibiotic biosynthesis. Nat Chem Biol. 2014 Apr;10(4):251-8. doi: 10.1038/nchembio.1456. Epub 2014 Feb 16. PubMed PMID: 24531841; PubMed Central PMCID: PMC3961552. 4. Gaudelli NM, Townsend CA. Stereocontrolled syntheses of peptide thioesters containing modified seryl residues as probes of antibiotic biosynthesis. J Org Chem. 2013 Jul 5;78(13):6412-26. doi: 10.1021/jo4007893. Epub 2013 Jun 18. Erratum in: J Org Chem. 2013 Nov 1;78(21):11115. PubMed PMID: 23758494; PubMed Central PMCID: PMC3898789.