TargetMol

Ivacaftor

Product Code:
 
TAR-T2588
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2588-1mg1mg£96.00
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TAR-T2588-5mg5mg£130.00
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TAR-T2588-1mL1 mL * 10 mM (in DMSO)£136.00
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TAR-T2588-10mg10mg£174.00
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TAR-T2588-25mg25mg£244.00
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TAR-T2588-50mg50mg£327.00
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TAR-T2588-100mg100mg£455.00
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TAR-T2588-500mg500mg£914.00
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This product comes from: United States.
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Further Information

Bioactivity:
Ivacaftor (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively.
CAS:
873054-44-5
Formula:
C24H28N2O3
Molecular Weight:
392.499
Pathway:
Autophagy; Membrane transporter/Ion channel
Purity:
0.99
SMILES:
CC(C)(C)c1cc(c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O)C(C)(C)C
Target:
CFTR; Autophagy

References

1. Van Goor F, et al. Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18825-30. 2. Delaunay JL, et al. Functional defect of variants in the adenosine triphosphate-binding sites of ABCB4 and their rescue by the cystic fibrosis transmembrane conductance regulator potentiator, ivacaftor (VX-770). Hepatology. 2017 Feb;65(2):560-570. 3. Hadida S, et al. Discovery of N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, ivacaftor), a potent and orally bioavailable CFTR potentiator. J Med Chem. 2014 Dec 11;57(23):9776-9.