TargetMol

Oxazidione

Product Code:
 
TAR-T25909
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25909-5mg5mg£850.00
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TAR-T25909-50mg50mg£1,661.00
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Quantity:
TAR-T25909-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Oxazidione is an anticoagulant compound.
CAS:
27591-42-0
Formula:
C20H19NO3
Molecular Weight:
321.376
Purity:
0.98
SMILES:
O=C1c2ccccc2C(=O)C1(CN1CCOCC1)c1ccccc1

References

1. Kim Y, Anderson MO, Park J, Lee MG, Namkung W, Verkman AS. Benzopyrimido-pyrrolo-oxazine-dione (R)-BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATP. Mol Pharmacol. 2015 Oct;88(4):689-96. doi: 10.1124/mol.115.098368. Epub 2015 Jul 14. PubMed PMID: 26174774; PubMed Central PMCID: PMC4576686. 2. Snyder DS, Tradtrantip L, Battula S, Yao C, Phuan PW, Fettinger JC, Kurth MJ, Verkman AS. ABSOLUTE CONFIGURATION AND BIOLOGICAL PROPERTIES OF ENANTIOMERS OF CFTR INHIBITOR BPO-27. ACS Med Chem Lett. 2013 May 9;4(5):456-459. PubMed PMID: 23814642; PubMed Central PMCID: PMC3694630. 3. Snyder DS, Tradtrantip L, Yao C, Kurth MJ, Verkman AS. Potent, metabolically stable benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR inhibitors for polycystic kidney disease. J Med Chem. 2011 Aug 11;54(15):5468-77. doi: 10.1021/jm200505e. Epub 2011 Jul 12. PubMed PMID: 21707078; PubMed Central PMCID: PMC3314378. 4. Mu F, Lee DJ, Pryor DE, Hamel E, Cushman M. Synthesis and investigation of conformationally restricted analogues of lavendustin A as cytotoxic inhibitors of tubulin polymerization. J Med Chem. 2002 Oct 10;45(21):4774-85. PubMed PMID: 12361405.