TargetMol

Pseudomonic acid C

Product Code:
 
TAR-T25997
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T25997-5mg5mg£254.00
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Further Information

Bioactivity:
Pseudomonic acid C is the analogue of Pseudomonic Acid D which is an antibiotic agent from Pseudomonas fluorescens.
CAS:
71980-98-8
Formula:
C26H44O8
Molecular Weight:
484.63
Purity:
0.98
SMILES:
C[C@H](O)[C@H](C)C=CC[C@H]1CO[C@@H](CC(C)=CC(=O)OCCCCCCCCC(O)=O)[C@H](O)[C@@H]1O

References

1. Sridhar Y, Srihari P. A unified strategy for the synthesis of the C1-C14 fragment of marinolic acids, mupirocins, pseudomonic acids and thiomarinols: total synthesis of pseudomonic acid methyl monate C. Org Biomol Chem. 2014 May 14;12(18):2950-9. doi: 10.1039/c4ob00025k. PubMed PMID: 24691713. 2. Broom NJ, Cassels R, Cheng HY, Elder JS, Hannan PC, Masson N, O'Hanlon PJ, Pope A, Wilson JM. The chemistry of pseudomonic acid. 17. Dual-action C-1 oxazole derivatives of pseudomonic acid having an extended spectrum of antibacterial activity. J Med Chem. 1996 Aug 30;39(18):3596-600. PubMed PMID: 8784459. 3. Fritz E, Fekete A, Lintelmann J, Schmitt-Kopplin P, Meckenstock RU. Isolation of two Pseudomonas strains producing pseudomonic acid A. Syst Appl Microbiol. 2009 Feb;32(1):56-64. doi: 10.1016/j.syapm.2008.11.001. Epub 2008 Dec 12. PubMed PMID: 19070447. 4. Hothersall J, Wu J, Rahman AS, Shields JA, Haddock J, Johnson N, Cooper SM, Stephens ER, Cox RJ, Crosby J, Willis CL, Simpson TJ, Thomas CM. Mutational analysis reveals that all tailoring region genes are required for production of polyketide antibiotic mupirocin by pseudomonas fluorescens: pseudomonic acid B biosynthesis precedes pseudomonic acid A. J Biol Chem. 2007 May 25;282(21):15451-61. Epub 2007 Mar 23. PubMed PMID: 17383964.