TargetMol

Nolatrexed dihydrochloride

Product Code:
 
TAR-T2627
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2627-5mg5mg£117.00
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TAR-T2627-10mg10mg£137.00
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TAR-T2627-25mg25mg£211.00
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TAR-T2627-50mg50mg£334.00
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This product comes from: United States.
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Further Information

Bioactivity:
Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity.
CAS:
152946-68-4
Formula:
C14H14Cl2N4OS
Molecular Weight:
357.25
Pathway:
Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Purity:
0.98
SMILES:
Cl.Cl.Cc1ccc2nc(N)[nH]c(=O)c2c1Sc1ccncc1
Target:
DNA/RNA Synthesis

References

1. Hughes AN, et al. Br J Y. 2000 May;82(9):1519-27.