TargetMol

Tyropeptin A-4

Product Code:
 
TAR-T26301
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26301-5mg5mg£1,091.00
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TAR-T26301-50mg50mg£2,143.00
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Quantity:
TAR-T26301-100mg100mg£2,801.00
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This product comes from: United States.
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Further Information

Bioactivity:
Tyropeptin A-4 is used as a proteasome inhibitor.
CAS:
688737-89-5
Formula:
C31H41N3O6
Molecular Weight:
551.684
Purity:
0.98
SMILES:
CC(C)[C@H](N(C(Cc1ccc(O)cc1)C=O)C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CC1CCCCC1)C(N)=O

References

1. Momose I, Abe H, Watanabe T, Ohba S, Yamazaki K, Dan S, Yamori T, Masuda T, Nomoto A. Antitumor effects of tyropeptin-boronic acid derivatives: New proteasome inhibitors. Cancer Sci. 2014 Dec;105(12):1609-15. doi: 10.1111/cas.12542. Epub 2014 Oct 21. PubMed PMID: 25251038; PubMed Central PMCID: PMC4317970. 2. Watanabe T, Abe H, Momose I, Takahashi Y, Ikeda D, Akamatsu Y. Structure-activity relationship of boronic acid derivatives of tyropeptin: proteasome inhibitors. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5839-42. doi: 10.1016/j.bmcl.2010.07.122. Epub 2010 Aug 1. PubMed PMID: 20727746. 3. Steverding D, Pemberton AJ, Royle H, Spackman RW, Rivett AJ. Evaluation of the anti-trypanosomal activity of tyropeptin A. Planta Med. 2006 Jun;72(8):761-3. Epub 2006 May 29. PubMed PMID: 16732530. 4. Momose I, Umezawa Y, Hirosawa S, Iinuma H, Ikeda D. Structure-based design of derivatives of tyropeptin A as the potent and selective inhibitors of mammalian 20S proteasome. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1867-71. PubMed PMID: 15780623.