TargetMol

Vorozole

Product Code:
 
TAR-T26322
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26322-1mg1mg£224.00
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TAR-T26322-5mg5mg£456.00
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TAR-T26322-10mg10mg£622.00
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TAR-T26322-25mg25mg£938.00
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TAR-T26322-50mg50mg£1,259.00
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This product comes from: United States.
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Further Information

Bioactivity:
Vorozole is a third-generation inhibitor of aromatase (cytochrome P450 19A1).
CAS:
118949-22-7
Formula:
C16H13ClN6
Molecular Weight:
324.77
Pathway:
Endocrinology/Hormones|Metabolism
Purity:
0.98
SMILES:
Cn1nnc2ccc(cc12)C(c1ccc(Cl)cc1)n1cncn1
Target:
Aromatase|P450

References

1. Raymond L, Rayani N, Polson G, Sikorski K, Lian A, VanAlstine-Parris MA. Determining the IC 50 Values for Vorozole and Letrozole, on a Series of Human Liver Cytochrome P450s, to Help Determine the Binding Site of Vorozole in the Liver. Enzyme Res. 2015;2015:321820. doi: 10.1155/2015/321820. Epub 2015 Nov 9. PubMed PMID: 26635974; PubMed Central PMCID: PMC4655258. 2. Biegon A, Alexoff DL, Kim SW, Logan J, Pareto D, Schlyer D, Wang GJ, Fowler JS. Aromatase imaging with [N-methyl-11C]vorozole PET in healthy men and women. J Nucl Med. 2015 Apr;56(4):580-5. doi: 10.2967/jnumed.114.150383. Epub 2015 Feb 19. PubMed PMID: 25698781. 3. Logan J, Kim SW, Pareto D, Telang F, Wang GJ, Fowler JS, Biegon A. Kinetic analysis of [11C]vorozole binding in the human brain with positron emission tomography. Mol Imaging. 2014;13:1-12. PubMed PMID: 24824855. 4. Pareto D, Biegon A, Alexoff D, Carter P, Shea C, Muench L, Xu Y, Fowler JS, Kim SW, Logan J. In vivo imaging of brain aromatase in female baboons: [11C]vorozole kinetics and effect of the menstrual cycle. Mol Imaging. 2013 Nov-Dec;12(8). doi: 10.2310/7290.2013.00068. PubMed PMID: 24447618.