TargetMol

A 62176

Product Code:
 
TAR-T26425
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26425-5mg5mg£850.00
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Quantity:
TAR-T26425-50mg50mg£1,661.00
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Quantity:
TAR-T26425-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
A 62176 is a potent topoisomerase inhibitor with antineoplastic activity.
CAS:
148201-53-0
Formula:
C20H17ClFN3O4
Molecular Weight:
417.82
Purity:
0.98
SMILES:
Cl.NC1CCCN1c1c(F)cc2c3c1oc1ccccc1n3cc(C(O)=O)c2=O

References

1. Kim HL, Jeon KH, Jun KY, Choi Y, Kim DK, Na Y, Kwon Y. A-62176, a potent topoisomerase inhibitor, inhibits the expression of human epidermal growth factor receptor 2. Cancer Lett. 2012 Dec 1;325(1):72-9. doi: 10.1016/j.canlet.2012.06.004. Epub 2012 Jun 23. PubMed PMID: 22732416. 2. Yu H, Kwok Y, Hurley LH, Kerwin SM. Efficient, Mg(2+)-dependent photochemical DNA cleavage by the antitumor quinobenzoxazine (S)-A-62176. Biochemistry. 2000 Aug 22;39(33):10236-46. PubMed PMID: 10956013. 3. Fan JY, Sun D, Yu H, Kerwin SM, Hurley LH. Self-assembly of a quinobenzoxazine-Mg2+ complex on DNA: a new paradigm for the structure of a drug-DNA complex and implications for the structure of the quinolone bacterial gyrase-DNA complex. J Med Chem. 1995 Feb 3;38(3):408-24. PubMed PMID: 7853333. 4. Kwok Y, Zeng Q, Hurley LH. Structural insight into a quinolone-topoisomerase II-DNA complex. Further evidence for a 2:2 quinobenzoxazine-mg2+ self-assembly model formed in the presence of topoisomerase ii. J Biol Chem. 1999 Jun 11;274(24):17226-35. PubMed PMID: 10358081.