TargetMol

A-317920

Product Code:
 
TAR-T26478
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26478-5mg5mg£850.00
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TAR-T26478-50mg50mg£1,661.00
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Quantity:
TAR-T26478-100mg100mg£2,079.00
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  • Further Information
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Further Information

Bioactivity:
A-317920 is an inverse agonist radioligand.
CAS:
360551-59-3
Formula:
C25H31N3O5
Molecular Weight:
453.539
Purity:
0.98
SMILES:
C[C@@H](NC(=O)c1ccco1)C(=O)N1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)CC1

References

1. Yao BB, Witte DG, Miller TR, Carr TL, Kang CH, Cassar S, Faghih R, Bennani YL, Surber BW, Hancock AA, Esbenshade TA. Use of an inverse agonist radioligand [3H]A-317920 reveals distinct pharmacological profiles of the rat histamine H3 receptor. Neuropharmacology. 2006 Mar;50(4):468-78. PubMed PMID: 16316670. 2. Esbenshade TA, Yao BB, Witte DG, Carr TL, Sharma R, Baranowski JL, Krueger KM, Miller TR, Surber BW, Faghih R, Hancock AA. Use of novel, non-imidazole inverse agonist radioligands to define histamine H3 receptor pharmacology. Inflamm Res. 2005 Apr;54 Suppl 1:S46-7. PubMed PMID: 15928830. 3. Fox GB, Esbenshade TA, Pan JB,et al. Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological characterization and broad preclinical efficacy in cognition and schizophrenia of a potent and selective histamine H3 receptor antagonist. J Pharmacol Exp Ther. 2005 Apr;313(1):176-90. PubMed PMID: 15608077. 4. Yao BB, Witte DG, Miller TR, Krueger KM, Carr TL, Kang CH, Faghih R, Bennani YL, Esbenshade TA, Hancock AA. In vitro pharmacological properties of two novel non-imidazole H3 receptor (H3R) antagonists. Inflamm Res. 2003 Apr;52 Suppl 1:S45-6. PubMed PMID: 12755405.