TargetMol

ADCI

Product Code:
 
TAR-T26564
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26564-5mg5mg£1,010.00
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TAR-T26564-50mg50mg£1,982.00
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Quantity:
TAR-T26564-100mg100mg£2,560.00
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  • Further Information
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Further Information

Bioactivity:
ADCI is an inhibitor of voltage-activated sodium channels and N-methyl-D-aspartate (NMDA)-receptor-gated channels. Inhibition of sodium channels by ADCI was voltage dependent. High doses of ADCI increased dopamine metabolism in the prefrontal cortex and/or in the nucleus accumbens, but not in the dorsal striatum.
CAS:
124070-15-1
Formula:
C16H14N2O
Molecular Weight:
250.301
Purity:
0.98
SMILES:
NC(=O)C12NC(Cc3ccccc13)c1ccccc21

References

1. Sun L, Lin SS. The anticonvulsant SGB-017 (ADCI) blocks voltage-gated sodium channels in rat and human neurons: comparison with carbamazepine. Epilepsia. 2000 Mar;41(3):263-70. PubMed PMID: 10714396. 2. Geter-Douglass B, Witkin JM. Behavioral effects and anticonvulsant efficacies of low-affinity, uncompetitive NMDA antagonists in mice. Psychopharmacology (Berl). 1999 Oct;146(3):280-9. PubMed PMID: 10541728. 3. Bubser M, Zadow B, Kronthaler UO, Felsheim U, R?ckert NG, Schmidt WJ. Behavioural pharmacology of the non-competitive NMDA antagonists dextrorphan and ADCI: relations between locomotor stimulation, anticataleptic potential and forebrain dopamine metabolism. Naunyn Schmiedebergs Arch Pharmacol. 1997 Jun;355(6):767-73. PubMed PMID: 9205962. 4. Grant KA, Colombo G, Grant J, Rogawski MA. Dizocilpine-like discriminative stimulus effects of low-affinity uncompetitive NMDA antagonists. Neuropharmacology. 1996;35(12):1709-19. PubMed PMID: 9076750.