TargetMol

ADL-5747 (HCl)

Product Code:
 
TAR-T26566
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26566-5mg5mg£930.00
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TAR-T26566-50mg50mg£1,821.00
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Quantity:
TAR-T26566-100mg100mg£2,319.00
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Further Information

Bioactivity:
ADL-5747, an opioid delta receptor agonist, is used potentially for the treatment of pain.
CAS:
1187653-56-0
Formula:
C24H29ClN2O3
Molecular Weight:
428.96
Purity:
0.98
SMILES:
Cl.CCN(CC)C(=O)c1ccc(C2=CC3(CCNCC3)Oc3ccccc23)c(O)c1

References

1. Le Bourdonnec B, Windh RT, Leister LK, Zhou QJ, Ajello CW, Gu M, Chu GH, Tuthill PA, Barker WM, Koblish M, Wiant DD, Graczyk TM, Belanger S, Cassel JA, Feschenko MS, Brogdon BL, Smith SA, Derelanko MJ, Kutz S, Little PJ, DeHaven RN, DeHaven-Hudkins DL, Dolle RE. Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747). J Med Chem. 2009 Sep 24;52(18):5685-702. doi: 10.1021/jm900773n. PubMed PMID: 19694468. 2. Nozaki C, Le Bourdonnec B, Reiss D, Windh RT, Little PJ, Dolle RE, Kieffer BL, Gav?riaux-Ruff C. ?-Opioid mechanisms for ADL5747 and ADL5859 effects in mice: analgesia, locomotion, and receptor internalization. J Pharmacol Exp Ther. 2012 Sep;342(3):799-807. doi: 10.1124/jpet.111.188987. PubMed PMID: 22700431; PubMed Central PMCID: PMC3422521.