TargetMol

ADX71441

Product Code:
 
TAR-T26569
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26569-5mg5mg£1,010.00
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TAR-T26569-50mg50mg£1,982.00
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Quantity:
TAR-T26569-100mg100mg£2,560.00
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  • Further Information
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Further Information

Bioactivity:
ADX71441 is a GABAB positive allosteric modulator (PAM). ADX71441 increases urinary latencies and reduces the number of urinary events and the total and average urinary volumes. ADX71441 may also mitigate alcoholism and have analgesic effects in the bladder.
CAS:
1207440-88-7
Formula:
C19H15ClF2N4O4
Molecular Weight:
436.8
Purity:
0.98
SMILES:
COc1nn(-c2ccc(F)c(NC(C)=O)c2)c(=O)n(Cc2ccc(Cl)c(F)c2)c1=O

References

1. Hwa LS, Kalinichev M, Haddouk H, Poli S, Miczek KA. Reduction of excessive alcohol drinking by a novel GABAB receptor positive allosteric modulator ADX71441 in mice. Psychopharmacology (Berl). 2014 Jan;231(2):333-43. doi: 10.1007/s00213-013-3245-z. Epub 2013 Aug 22. PubMed PMID: 23975038; PubMed Central PMCID: PMC3947346. 2. Kalinichev M, Palea S, Haddouk H, Royer-Urios I, Guilloteau V, Lluel P, Schneider M, Saporito M, Poli S. ADX71441, a novel, potent and selective positive allosteric modulator of the GABA(B) receptor, shows efficacy in rodent models of overactive bladder. Br J Pharmacol. 2014 Feb;171(4):995-1006. doi: 10.1111/bph.12517. PubMed PMID: 24224799; PubMed Central PMCID: PMC3925038. 3. Kannampalli P, Poli SM, Bol?a C, Sengupta JN. Analgesic effect of ADX71441, a positive allosteric modulator (PAM) of GABA(B) receptor in a rat model of bladder pain. Neuropharmacology. 2017 Nov;126:1-11. doi: 10.1016/j.neuropharm.2017.08.023. Epub 2017 Aug 18. PubMed PMID: 28823612. 4. Kalinichev M, Girard F, Haddouk H, Rouillier M, Riguet E, Royer-Urios I, Mutel V, L?tjens R, Poli S. The drug candidate, ADX71441, is a novel, potent and selective positive allosteric modulator of the GABA(B) receptor with a potential for treatment of anxiety, pain and spasticity. Neuropharmacology. 2017 Mar 1;114:34-47. doi: 10.1016/j.neuropharm.2016.11.016. Epub 2016 Nov 23. PubMed PMID: 27889489.