TargetMol

AUY954 HCl

Product Code:
 
TAR-T26685
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26685-5mg5mg£850.00
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TAR-T26685-50mg50mg£1,661.00
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Quantity:
TAR-T26685-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
AUY-954 is a potent and selective S1P(1) modulator. AUY-954 prevents experimental autoimmune neuritis in rats.
CAS:
820240-78-6
Formula:
C25H21ClF3NO2S
Molecular Weight:
491.95
Purity:
0.98
SMILES:
Cl.OC(=O)CCNCc1ccc2sc(cc2c1)-c1ccc(-c2ccccc2)c(c1)C(F)(F)F

References

1. Gaire BP, Lee CH, Sapkota A, Lee SY, Chun J, Cho HJ, Nam TG, Choi JW. Identification of Sphingosine 1-Phosphate Receptor Subtype 1 (S1P(1)) as a Pathogenic Factor in Transient Focal Cerebral Ischemia. Mol Neurobiol. 2017 Mar 25. doi: 10.1007/s12035-017-0468-8. [Epub ahead of print] PubMed PMID: 28343295. 2. T?lle M, Kl?ckl L, Wiedon A, Zidek W, van der Giet M, Schuchardt M. Regulation of endothelial nitric oxide synthase activation in endothelial cells by S1P1 and S1P3. Biochem Biophys Res Commun. 2016 Aug 5;476(4):627-34. doi: 10.1016/j.bbrc.2016.06.009. Epub 2016 Jun 7. PubMed PMID: 27282481. 3. O'Sullivan C, Schubart A, Mir AK, Dev KK. The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures. J Neuroinflammation. 2016 Feb 8;13:31. doi: 10.1186/s12974-016-0494-x. PubMed PMID: 26856814; PubMed Central PMCID: PMC4746808. 4. Montrose DC, Scherl EJ, Bosworth BP, Zhou XK, Jung B, Dannenberg AJ, Hla T. S1P? localizes to the colonic vasculature in ulcerative colitis and maintains blood vessel integrity. J Lipid Res. 2013 Mar;54(3):843-51. doi: 10.1194/jlr.M034108. Epub 2013 Jan 7. PubMed PMID: 23296878; PubMed Central PMCID: PMC3617958.