TargetMol

AZD-9164 bromide

Product Code:
 
TAR-T26724
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26724-5mg5mg£850.00
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TAR-T26724-50mg50mg£1,661.00
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Quantity:
TAR-T26724-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
AMG-221 is a potent and selective 11β-HSD1 inhibitor. AMG 221 potently blocked 11β-HSD1 activity, producing sustained inhibition for the 24-hour study duration as measured in ex vivo adipose samples. AMG-221 decreased fed blood glucose and insulin levels and reduced body weight in diet-induced obesity mice.
CAS:
1034916-72-7
Formula:
C29H38BrFN2O2
Molecular Weight:
545.537
Purity:
0.98
SMILES:
[Br-].C[C@@](N1CCCCC1)(C(=O)O[C@H]1C[N+]2(CCc3ccc(F)cc3)CCC1CC2)c1ccccc1

References

1. Bergenholm L, Collins T, Evans ND, Chappell MJ, Parkinson J. PKPD modelling of PR and QRS intervals in conscious dogs using standard safety pharmacology data. J Pharmacol Toxicol Methods. 2016 May-Jun;79:34-44. doi: 10.1016/j.vascn.2016.01.002. PubMed PMID: 26780675. 2. Jorup C, Bengtsson T, Strandg?rden K, Sj?bring U. Transient paradoxical bronchospasm associated with inhalation of the LAMA AZD9164: analysis of two Phase I, randomised, double-blind, placebo-controlled studies. BMC Pulm Med. 2014 Mar 27;14:52. doi: 10.1186/1471-2466-14-52. PubMed PMID: 24669829; PubMed Central PMCID: PMC3976047. 3. Bjermer L, Bengtsson T, Jorup C, L?tvall J. Local and systemic effects of inhaled AZD9164 compared with tiotropium in patients with COPD. Respir Med. 2013 Jan;107(1):84-90. doi: 10.1016/j.rmed.2012.09.014. PubMed PMID: 23098686. 4. Silvester S, Zang F. Overcoming non-specific adsorption issues for AZD9164 in human urine samples: consideration of bioanalytical and metabolite identification procedures. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Apr 15;893-894:134-43. doi: 10.1016/j.jchromb.2012.03.004. PubMed PMID: 22440890.