TargetMol

BBR 2160

Product Code:
 
TAR-T26751
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T26751-5mg5mg£850.00
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TAR-T26751-50mg50mg£1,661.00
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TAR-T26751-100mg100mg£2,079.00
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Further Information

Bioactivity:
BBR 2160 is a dihydropyridine derivative belonging to the group of the so-called tiampidine. BBR 2160 has calcium-antagonistic properties in cardiac tissue. Intracellular microelectrodes have been used to characterize the electrophysiological properties of BBR 2160 on guinea-pig papillary muscle and sheep Purkinje fibres. BBR 2160 (10(-7) and 10(-6) M) dose dependently decreased the contractility of driven papillary muscle and Purkinje fibre. This effect was associated with a lowering of the plateau phase and a shortening of action potential duration in papillary muscle.
CAS:
118587-22-7
Formula:
C21H25N3O7S
Molecular Weight:
463.51
Purity:
0.98
SMILES:
CCOC(=O)C1=C(CSCCNC=O)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC

References

1. Barbieri M, Masini I, Porciatti F, Cerbai E, Mugelli A. Cardiac electrophysiological effects of a new dihydropyridine calcium antagonist (BBR 2160). Pharmacol Res. 1991 Jan;23(1):87-94. PubMed PMID: 2047363. 2. Barbieri M, Cerbai E, Masini I, Porciatti F, Visentin S, Mugelli A. Effect of BBR 2160 on ICa recorded from guinea-pig isolated myocytes. Pharmacol Res. 1990 Sep-Oct;22 Suppl 3:121-2. PubMed PMID: 2097624.