TargetMol

BH3I-2'

Product Code:
 
TAR-T26789
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26789-5mg5mg£850.00
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Quantity:
TAR-T26789-50mg50mg£1,661.00
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Quantity:
TAR-T26789-100mg100mg£2,079.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
BH3I-2' is a cell-permeable BH3 mimetic. BH3I-2' induces apoptosis by specifically preventing BH3 domain-mediated interactions between pro-apoptotic and anti-apoptotic members of the Bcl-2 family, thereby blocking the interaction between Bcl-x and Bak BH3 by targeting the Bcl-x binding pocket.
CAS:
315195-18-7
Formula:
C19H11Cl3INO4S
Molecular Weight:
582.61
Purity:
0.98
SMILES:
Oc1c(I)cc(Cl)cc1C(=O)Nc1cc(ccc1Cl)S(=O)(=O)c1ccc(Cl)cc1

References

1. Gerasimenko J, Ferdek P, Fischer L, Gukovskaya AS, Pandol SJ. Inhibitors of Bcl-2 protein family deplete ER Ca2+ stores in pancreatic acinar cells. Pflugers Arch. 2010 Oct;460(5):891-900. doi: 10.1007/s00424-010-0859-4. Epub 2010 Jul 9. PubMed PMID: 20617337; PubMed Central PMCID: PMC2937140.